如果您熟悉用于治疗焦虑症的认知行为治疗(CBT),您也可能熟悉暴露治疗,这是一个CBT技术,即面临焦虑的原因,以便重新评估现在的实际危险,并学习健康188体育平台app方式处理由此产生的恐惧。例如,如果您害怕高度,曝光疗法可能会逐渐将您暴露于不同的高度水平,同时教导您更好的策略来管理它创造的压力。暴露治疗可以非常有效 - 在成功的暴露中,恐惧可以从80%〜90%的高痛苦测量开始,并且末端明显更低,10%至20%。理想情况下,这种学习过程应继续通过恐惧的对象或事件遇到患者报告降低的痛苦评级。

While effective, using exposure therapy to learn that a feared event or object is not dangerous takes time, as a patient will typically need to successfully confront the feared stimuli repeatedly to see lowered distress ratings. However, recent research has uncovered that there may be a way to speed up the benefits of exposure therapy, or even enhance the results.

This Drug Can Boost Learning and Reduce Anxiety Symptoms Faster

D-环晶(DCS),一种作用于大脑中特定神经细胞受体的记忆增强药物,可用于改善在暴露实践期间发生的学习。DCS可以帮助您的细胞对神经递质谷氨酸的响应,这对于焦虑治疗的过程中重要的过程中是重要的。灭绝学习是暴露治疗的基础:它允许焦虑的患者了解令人担忧的结果不太可能发生。患有蜘蛛恐惧症的患者以反复暴露于蜘蛛而没有任何负面后果,患者了解到令人担忧的刺激不会导致恐惧的结果,并且能够克服他或她的恐惧。

The use of DCS can also lead to a faster reduction in anxiety symptoms over the course of treatment, and can even decrease the number of treatment sessions needed overall. The same holds true for symptoms of other anxiety-related problems, such as Social Anxiety Disorder,金宝博188滚球推荐, Obsessive-Compulsive Disorder, and Post-Traumatic Stress Disorder.

Because DCS is a memory enhancer and not an anxiolytic drug (a drug that reduces anxiety), taking DCS alone will not reduce anxiety. DCS only works to reduce anxiety symptoms in conjunction with exposure procedures, as it works to enhance the learning that takes place during therapy (i.e., by acting to boost the memory).

DCS副作用是最小的,但剂量计时仍然不确定

Whenused as a cognitive enhancer in conjunction with exposure therapy, doses of 50 and 250 milligrams of DCS are used, usually just for a few weeks. At this dose, DCS side effects are comparable to that of a placebo, with no known or recorded side effects.

However,scientists don't yet fully understand the optimal dosing and dose timing (before or after fear subsides). As a recent study suggests, DCS's effectiveness may depend on the success of the exposure itself. In other words, only patients who react with anxiety during the exposure therapy and then experience a significant decrease in anxiety by the end of the exposure may benefit from the medication. The study suggests that in an unsuccessful exposure (i.e., when the patient's anxiety does not peak and then decrease), DCS may instead reinforce the anxious response.1

使用DCS增强曝光疗法的后续步骤

鉴于DCS尚未被FDA批准作为用于加强CBT焦虑的药物,目前对公众目前无法使用。然而,在三所大学进行了一项研究DCS在暴露治疗中的作用的新研究研究:波士顿大学,德克萨斯大学奥斯汀,隆隆大学。该研究将在暴露后担忧消退时,才能检查患者对患者的有效性。

If you feel anxious in social situations and live near one of the universities, please reach out to the appropriate contact for more information regarding possible participation in the clinical trial.

  • 波士顿大学/ **/
  • 德克萨斯大学奥斯汀/ **/
  • Rush University/**/
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Jeremy Schwartz, LCSW
Liz Matheis, Ph.D.
Andrea N. Niles, PhD
Courtney Benjamin Wolk, Ph.D.
Samuel Hunley, Ph.D.

注释

Sources

1Hofmann, SG. (2014). D-cycloserine for treating anxiety disorders: making good exposures better and bad exposures worse.PubMed.Retrieved fromhttp://www.ncbi.nlm.nih.gov/pubmed/24677604

Date of original publication:

Updated: January 29, 2018